FITC标记的富含GC启动子结合蛋白1/血管壁相连蛋白抗体
产品名称： FITC标记的富含GC启动子结合蛋白1/血管壁相连蛋白抗体
英文名称： Anti-GPBP1/FITC
产品编号： HZ-13503R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPBP1/FITC Conjugated antibody
FITC标记的富含GC启动子结合蛋白1/血管壁相连蛋白抗体
| 英文名称 | Anti-GPBP1/FITC |
| 中文名称 | FITC标记的富含GC启动子结合蛋白1/血管壁相连蛋白抗体 |
| 别 名 | Vasculin; DKFZp761C169; GC rich promoter binding protein 1; GC-rich promoter-binding protein 1; GPBP; Gpbp1; GPBP1_HUMAN; MGC126339; SSH6; Vascular wall linked; Vascular wall-linked protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPBP1/Vasculin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Vascular wall-linked protein, or Vasculin, is primarily expressed in the arterial wall and in plasma. It is also differentially expressed in human atherogenesis. Alternative splicing of exon 3 of the Vasculin gene produces three variants. Vasculin binds to and activates the minimal self-sufficient promoter element (MSPE) of the mouse Ada gene promoter and binds to and partially suppresses the GC-rich promoter of the nonhomologous human TOP2A gene promoter. It acts as a nuclear factor that can form complexes with TATA-binding proteins, transcription factors TFIIB and TFIIF, RNA polymerase II and p300. The regulated expression of Vasculin in plaques suggests that it may be involved in atherogenesis, and its presence in plasma may implicate Vasculin as a marker for atherosclerosis. Function: Functions as a GC-rich promoter-specific transactivating transcription factor. Subunit: Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP (By similarity). Subcellular Location: Nucleus. Cytoplasm. According to PubMed:12842993, it localizes to the cytoplasm. Tissue Specificity: Widely expressed. Some isoforms may be specifically expressed in veins and arteries (at protein level). Isoform 4 is widely expressed. Isoform 1, isoform 2 and isoform 3 may be specifically expressed in vascular smooth muscle cells. Similarity: Belongs to the vasculin family. Database links: Entrez Gene: 65056 Human Entrez Gene: 73274 Mouse Entrez Gene: 294734 Rat Entrez Gene: 613751 Cow SwissProt: Q0P5K1 Cow SwissProt: Q86WP2 Human SwissProt: Q9H0D4 Human SwissProt: Q9H785 Human SwissProt: Q3TQR2 Mouse SwissProt: Q6NXH3 Mouse SwissProt: Q6TYE7 Mouse SwissProt: Q8R252 Mouse Unigene: 17440 Cow Unigene: 444279 Human Unigene: 441830 Mouse Unigene: 57286 Mouse Unigene: 33325 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
血管壁连结蛋白，金vasculin，是由expressed in the动脉壁和等离子体。It is also差异expressed in Human atherogenesis。可变剪接的外显子3 of the vasculin生产三基因变体。vasculin binds to and the最小激活自我足够的启动子元素（MSPE）基因启动子和艾达of the小鼠binds to and partially suppresses the GC丰富的启动子nonhomologous TOP2A基因启动子的人。它的行为是核因子that can form复杂以及塔塔结合蛋白，转录因子TFIIB和tfiif RNA聚合酶II，和P300。the调节表达vasculin in板suggests that it may be involved in atherogenesis，and its presence等离子体可以有内在vasculin动脉粥样硬化的标志物。