TNFRSF8 monoclonal antibody, clone MEM-268 (FITC)
产品名称： TNFRSF8 monoclonal antibody, clone MEM-268 (FITC)
英文名称： TNFRSF8 monoclonal antibody, clone MEM-268 (FITC)
产品编号： MAB5099
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against TNFRSF8.
- Immunogen:
- Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line).
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody recognizes extracellular part of CD30 (Ki-1 antigen), a 105 KDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells.
- Form:
- Liquid
- Conjugation:
- FITC
- Isotype:
- IgG
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Maternal serum soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnancies.
Kusanovic JP, Romero R, Hassan SS, Gotsch F, Edwin S, Chaiworapongsa T, Erez O, Mittal P, Mazaki-Tovi S, Soto E, Than NG, Friel LA, Yoon BH, Espinoza J.J Matern Fetal Neonatal Med. 2007 Dec;20(12):867-78.
- 2.
- CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells.
Wright CW, Rumble JM, Duckett CS.J Biol Chem. 2007 Apr 6;282(14):10252-62. Epub 2007 Jan 29.
- 3.
- Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease.
Zeiser R, Nguyen VH, Hou JZ, Beilhack A, Zambricki E, Buess M, Contag CH, Negrin RS.Blood. 2007 Mar 1;109(5):2225-33. Epub 2006 Oct 26.
- Application Image
- Flow Cytometry
- Entrez GeneID:
- 943
- Gene Name:
- TNFRSF8
- Gene Alias:
- CD30,D1S166E,KI-1
- Gene Description:
- tumor necrosis factor receptor superfamily, member 8
- Omim ID:
- 153243
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- CD30 antigen,CD30L receptor,Ki-1 antigen,OTTHUMP00000001783,cytokine receptor CD30,lymphocyte activation antigen CD30
- Gene Pathway