PCSK9 (prodomain) monoclonal antibody, clone KS-2C8
产品名称： PCSK9 (prodomain) monoclonal antibody, clone KS-2C8
英文名称： PCSK9 (prodomain) monoclonal antibody, clone KS-2C8
产品编号： MAB8228
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant PCSK9.
- Immunogen:
- Recombinant His fusion protein corresponding to full length human PCSK9.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody detects endogenous mature form of PCSK9 prodomain, does not react with pro-form of PCSK9.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In 10 mM phosphate buffer, 150 mM NaCl, pH 7.5 (50% glycerol)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
Immunoprecipitation (1-2 ug/sample)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.
Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH.J Biol Chem. 2007 Jun 22;282(25):18602-12. Epub 2007 Apr 23.
- 2.
- Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.
Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD.J Clin Invest. 2006 Nov;116(11):2995-3005.
- 3.
- Effect of mutations in the PCSK9 gene on the cell surface LDL receptors.
Cameron J, Holla OL, Ranheim T, Kulseth MA, Berge KE, Leren TP.Hum Mol Genet. 2006 May 1;15(9):1551-8. Epub 2006 Mar 28.
- Entrez GeneID:
- 255738
- Gene Name:
- PCSK9
- Gene Alias:
- FH3,HCHOLA3,LDLCQ1,NARC-1,NARC1
- Gene Description:
- proprotein convertase subtilisin/kexin type 9
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq
- Other Designations:
- OTTHUMP00000009833,convertase subtilisin/kexin type 9 preproprotein,neural apoptosis regulated convertase 1
- Related Disease
- Alzheimer Disease
- Atherosclerosis
- Atherosclerosis
- Calcinosis
- Cardiovascular Diseases
- Chromosome Aberrations
- Chronic Disease
- Coronary Artery Disease
- Coronary Disease
- Dementia
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Hypercholesterolemia
- Hyperlipoproteinemia Type II
- Hypertension
- Hypobetalipoproteinemias
- Hypolipoproteinemias
- Kidney Diseases